Patrick Dempsey’s triumphant return to television is a high-stakes thriller with a compact 10-episode first season. The series, Memory of a Killer, follows a hitman grappling with early-onset Alzheimer’s, airing Mondays on Fox and streaming the next day on Hulu.
Memory of a Killer marks a major comeback for Patrick Dempsey, best known as Dr. Derek “McDreamy” Shepherd from Grey’s Anatomy. After an 11-season run on the ABC medical drama, Dempsey has returned to the small screen in a radically different role. He plays Angelo Doyle, a seemingly ordinary suburban dad who sells photocopiers by day and works as a hired assassin by night. The series, which premiered on Fox on January 25, 2026, delves into the high-tension world of a hitman whose two lives begin to dangerously collide as he starts showing signs of early-onset Alzheimer’s disease.
The first season of Memory of a Killer consists of 10 episodes, a decision that was crucial in attracting Dempsey back to a weekly television series. The actor had been hesitant to commit to another long-running show due to the demanding schedule and creative constraints. However, the creators’ promise of a “relatively short” first season was a key factor in his decision to sign on. This shorter format allows for a tight, propulsive narrative, a choice that echoes the structure of the source material, the 2003 Belgian film De Zaak Alzheimer, which also inspired the 2022 Liam Neeson film Memory.
Episode Release Schedule: From Premiere to Finale
The series kicked off with a two-night premiere event, designed to build momentum and hook viewers immediately. The first episode aired on Sunday, January 25, followed by the second episode on Monday, January 26. After this launch, the show settled into its regular Monday night time slot.
Here is the confirmed episode release schedule for season 1:
- January 25: Episode 1, “Pilot”
- January 26: Episode 2, “Ferryman”
- February 2: Episode 3, “Samurai”
- February 9: Episode 4
- February 16: Episode 5
- February 23: Episode 6
- March 2: Episode 7
- March 9: Episode 8
- March 16: Episode 9
- March 23: Episode 10 (Season Finale)
Where to Watch and What to Expect
New episodes of Memory of a Killer air every Monday at 9:00 p.m. ET on Fox. For cord-cutters and streaming enthusiasts, the series is available to stream the next day on Hulu. The show’s central premise— a hitman’s deteriorating memory becoming his greatest liability—creates a unique and compelling tension that sets it apart from other thrillers.
The cast is a major draw, featuring Dempsey alongside a powerhouse ensemble. Michael Imperioli plays Michael, Angelo’s older brother whose own Alzheimer’s disease is progressing rapidly. Gina Torres, Odeya Rush, Daniel David Stewart, and Richard Harmon also star, adding depth to the show’s complex web of characters and secrets. This blend of a beloved star with a fresh, high-concept plot makes Memory of a Killer one of the most anticipated new series of the year, promising a season of edge-of-your-seat television.
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